Cell penetrating antibodies

Pharmaceuticals, Vol. 6, Pages 320-339: Cell Penetration Properties of a Highly Efficient Mini Maurocalcine Peptide
Broadly neutralizing anti-HIV Maurocalcine is a highly potent cell-penetrating peptide isolated from the Tunisian scorpion Maurus palmatus. Many cell-penetrating peptide analogues have been derived from the full-length maurocalcine by internal cysteine substitutions and sequence truncation. Herein we have further characterized the cell-penetrating properties of one such peptide, MCaUF1-9, whose sequence matches that of the hydrophobic face of maurocalcine. This peptide shows very favorable cell-penetration efficacy compared to Tat, penetratin or polyarginine. The peptide appears so specialized in cell penetration that it seems hard to improve by site directed mutagenesis. A comparative analysis of the efficacies of similar peptides isolated from other toxin members of the same family leads to the identification of hadrucalcin’s hydrophobic face as an even better CPP. Protonation of the histidine residue at position 6 renders the cell penetration of MCaUF1-9 pH-sensitive. Greater cell penetration at acidic pH suggests that MCaUF1-9 can be used to specifically target cancer cells in vivo where tumor masses grow in more acidic environments.

Source: MDPI Publishing

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  • Avatar lil_red_ghost How might these antibodies influence the chemical reactions controlled by the enzymes?
    Nov 03, 2008 by lil_red_ghost | Posted in Biology

    Some antibodies act by binding to certain essential enzymes in the target bacteria. (a)how might these antibiotics influence the chemical reactions controlled by the enzymes? (b) What is the anticipated effect on the bacteria? On the person taking the antibiotic prescription?

    • In brief, the antibodies bind to the target bacteria to signal the cell that it is a foreign invader. In response, the body's immune system will destroy the bound bacteria by eating it up. The person taking the antibiotic prescription would have a high level of specific antibodies to fight the foreign invaders.